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Chemical Structure : KRCA-0008
CAS No.: 1472795-20-2
Catalog No.: PC-42979Not For Human Use, Lab Use Only.
KRCA-0008 is a potent, selective ALK inhibitor with IC50 of 12 nM (wt ALK), also is potent against various ALK mutants, including L1196M, F1174L, R1275Q, and C1156Y (IC50=5-75 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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KRCA-0008 is a potent, selective ALK inhibitor with IC50 of 12 nM (wt ALK), also is potent against various ALK mutants, including L1196M, F1174L, R1275Q, and C1156Y (IC50=5-75 nM).
KRCA-0008 weakly inhibits IR (IC50=210 nM), inhibits H3122 and BaF3 EML4-ALK L1196M cell proliferation with IC50 of 80 and 68 nM, respectively.
KRCA-0008 demonstrates in vivo efficacy comparable to Crizotinib in xenograft mice model, has drug-like properties without hERG concerns.
| M.Wt | 609.119 | |
| Formula | C30H37ClN8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Ethanone, 1,1'-[(5-chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bis- |
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1. Park CH, et al. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6192-6.
2. Kang CH, et al. Biochem Biophys Res Commun. 2015 Aug 28;464(3):762-7.
3. Lee HJ, et al. Arch Pharm Res. 2014;37(9):1130-8.
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