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Chemical Structure : KRCT-6j
Catalog No.: PC-72446Not For Human Use, Lab Use Only.
KRCT-6j is a potent and selective TYRO3 inhibitor, 300-fold selectivity for TYRO3 over both AXL and MerTK.
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KRCT-6j is a potent and selective TYRO3 inhibitor, 300-fold selectivity for TYRO3 over both AXL and MerTK.
KRCT-6j selectively inhibited the proliferation of TYRO3-overexpressing Ba/F3 cells, also suppressed csEV-stimulated cell migration of LNCaP-SL cells in a concentration-dependent manner.
KRCT-6j diminished csEV-induced membrane localization of F-actin, reversed the increased expression and nuclear localization of YAP stimulated by csEVs.
KRCT-6j significantly inhibited tumor growth in xenografts implanted with GR-H1993 cells when combined with gefitinib.
| M.Wt | 417.338 | |
| Formula | C20H22Cl2N6 | |
| Appearance | Solid | |
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1. Miso Park, et al. Cancer Res. 2021 Jul 1;81(13):3539-3553.
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