KRX-104130 | MCHR1 antagonist | Probechem Biochemicals

Chemical Structure : KRX-104130

KRX-104130 (KRX104130)

Catalog No.: PC-22854Not For Human Use, Lab Use Only.

KRX-104130 is a potent melanin-concentrating hormone receptor 1 (MCHR1) antagonist with IC50 of 0.02 uM, shows no cardiotoxicity.

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Biological Activity

KRX-104130 is a potent melanin-concentrating hormone receptor 1 (MCHR1) antagonist with IC50 of 0.02 uM, shows no cardiotoxicity.
KRX-104130 increased the expression of low-density lipoprotein receptor (LDLR), which induced cholesterol reduction in the gene expression analysis.
KRX-104130 showed a protective effect by reducing hepatic lipid accumulation, liver injury, and histopathological changes in NASH mouse model.

Physicochemical Properties

M.Wt	466.49
Formula	C24H24F2N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-((1H-indol-2-yl)methyl)piperidin-4-yl)-3-(6,7-difluoro-3-methoxyquinoxalin-2-yl)urea

References

1. Lim G, et al. Int J Mol Sci. 2022 Mar 30;23(7):3807.

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KRX-104130 (KRX104130)

Biological Activity

Physicochemical Properties

References

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