KS-99 |Cas:1344698-28-7 Buy KS-99 from ProbeChem, Global Biochemicals Supplier

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Chemical Structure : KS-99

KS-99 (KS99;KS 99)

Catalog No.: PC-70205Not For Human Use, Lab Use Only.

KS-99 (KS99) is a novel dual inhibitor of BTK and tubulin polymerization.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KS-99 (KS99) is a novel dual inhibitor of BTK and tubulin polymerization; interacts directly with the catalytic domain of BTK and inhibits phosphorylation at the Y223 residue and kinase activities; reduces the cell viability of MM and CD138+ cells (IC50=0.5-1 uM); inhibits the in vivo tumor growth of MM cells through the inhibition of BTK and tubulin.

Physicochemical Properties

M.Wt	466.147
Formula	C17H10Br2N2O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5,7-dibromo-1-(4-(thiocyanatomethyl)benzyl)indoline-2,3-dione

References

1. Pandey MK, et al. Exp Hematol. 2017 Jun 22. pii: S0301-472X(17)30233-3.

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KS-99 (KS99;KS 99)

Biological Activity

Physicochemical Properties

References

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