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KT-172

Chemical Structure : KT-172

CAS No.: 1402612-56-9

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KT-172 (KT172)

Catalog No.: PC-61839Not For Human Use, Lab Use Only.

KT-172 is a potent, selective inhibitor of DAGLβ with IC50 of 60 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KT-172 (KT172) is a potent, selective inhibitor of DAGLβ with IC50 of 60 nM.
    KT-172 displays selectivity over DAGLα, and negligible activity against other key enzymes involved in endocannabinoid signaling, including FAAH, MAGL, and ABHD11.
    KT-172 disrupts the lipid network involved in macrophage inflammatory responses, lowering 2-AG, as well as arachidonic acid and eicosanoids in mouse peritoneal macrophages.
    KT-172 possesses one remaining off-target ABHD6 (IC50=5 nM).

    Physicochemical Properties

    M.Wt 452.55
    Formula C28H28N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2-Benzylpiperidin-1-yl)(4-(2'-methoxy-[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)methanone

    References

    1. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007.

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