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Chemical Structure : KT-172
Catalog No.: PC-61839Not For Human Use, Lab Use Only.
KT-172 is a potent, selective inhibitor of DAGLβ with IC50 of 60 nM.
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KT-172 (KT172) is a potent, selective inhibitor of DAGLβ with IC50 of 60 nM.
KT-172 displays selectivity over DAGLα, and negligible activity against other key enzymes involved in endocannabinoid signaling, including FAAH, MAGL, and ABHD11.
KT-172 disrupts the lipid network involved in macrophage inflammatory responses, lowering 2-AG, as well as arachidonic acid and eicosanoids in mouse peritoneal macrophages.
KT-172 possesses one remaining off-target ABHD6 (IC50=5 nM).
| M.Wt | 452.55 | |
| Formula | C28H28N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hsu KL, et al. Nat Chem Biol. 2012 Dec;8(12):999-1007.
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