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KT-5823

Chemical Structure : KT-5823

CAS No.: 126643-37-6

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KT-5823 (KT5823)

Catalog No.: PC-63045Not For Human Use, Lab Use Only.

KT-5823 is a potent, highly specific PKG (cGMP-dependent protein kinase) inhibitor with Ki of 0.234 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KT-5823 is a potent, highly specific PKG (cGMP-dependent protein kinase) inhibitor with Ki of 0.234 uM.
KT-5823 also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively.
KT-5823 arresst cells at a later time that is approximately 6 h after the G0/G1 boundary.

Physicochemical Properties

M.Wt 495.525
Formula C29H25N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, [9S-(9α,10β,12α)]-

References

1. Gadbois DM, et al. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30.

2. Burkhardt M, et al. J Biol Chem. 2000 Oct 27;275(43):33536-41.

3. Beyer S, et al. Endocrinology. 2011 Mar;152(3):782-92.

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