KT195 (ML 295) is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM.
KT195 displays negligible activity against other serine hydrolases such as DAGLβ.
KT195 induce a significant accumulation of 2-AG in Neuro2a cells.
KT195 inhibits A23187-stimulated arachidonic acid release (IC50=0.7 uM) and LDH release from IMLF−/−.
KT195 inhibits MPTP formation and cell death, blocks mitochondrial calcium uptak.
