KTX-582 | IRAK4 PROTAC | Probechem Biochemicals

Chemical Structure : KTX-582

KTX-582 (KTX582)

Catalog No.: PC-26138Not For Human Use, Lab Use Only.

KTX-582 is a potent, selective IRAK4 PROTAC degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively, induces apoptosis in MYD88MT DLBCL, induces in vivo tumor regressions in lymphoma model.

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Biological Activity

Physicochemical Properties

M.Wt	872.95
Formula	C45H51F3N8O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(trans-4-(((3-(trans-3-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)cyclobutoxy)propyl)(methyl)amino)methyl)cyclohexyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide

References

1. Patent WO/2020/113233.

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KTX-582 (KTX582)

Biological Activity

Physicochemical Properties

References

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