Catalog No.: PC-42831Not For Human Use, Lab Use Only.
KU-55933 (KU55933) is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM, >100-fold selectivity against other members of the PIKK family kinases.
KU-55933 (KU55933) is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM, >100-fold selectivity against other members of the PIKK family kinases.
KU-55933 inhibits ATM-dependent p53 Ser15 phosphorylation in U2OS osteosarcoma cells with IC50 of 0.3 uM.
KU-55933 sensitizes the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin.
KU-55933 also suppresses the replication of both wild-type and drug-resistant HIV-1 by sensitizing cells to retrovirus-induced cell death.
