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Chemical Structure : KU-55933
CAS No.: 587871-26-9
Catalog No.: PC-42831Not For Human Use, Lab Use Only.
KU-55933 (KU55933) is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM, >100-fold selectivity against other members of the PIKK family kinases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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KU-55933 (KU55933) is a potent, specific, ATP-competitive inhibitor of ATM with Ki/IC50 of 2.2/13 nM, >100-fold selectivity against other members of the PIKK family kinases.
KU-55933 inhibits ATM-dependent p53 Ser15 phosphorylation in U2OS osteosarcoma cells with IC50 of 0.3 uM.
KU-55933 sensitizes the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin.
KU-55933 also suppresses the replication of both wild-type and drug-resistant HIV-1 by sensitizing cells to retrovirus-induced cell death.
| M.Wt | 395.4946 | |
| Formula | C21H17NO3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 80 mg/mL (Need ultrasonic) |
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| Chemical Name/SMILES |
4H-Pyran-4-one, 2-(4-morpholinyl)-6-(1-thianthrenyl)- |
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1. Hickson I, et al. Cancer Res. 2004 Dec 15;64(24):9152-9.
2. Lau A, et al. Nat Cell Biol. 2005 May;7(5):493-500.
3. Soriani A, et al. Blood. 2009 Apr 9;113(15):3503-11.
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