KW-2449 is a multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively.
KW-2449 has little effect on PDGFRβ, IGF-1R, EGFR, and various serine/threonine kinases at 1 uM.
KW-2449 exhibits potent growth inhibitory effects on leukemia cells with FLT3 mutations, resulting in the down-regulation of phosphorylated-FLT3/STAT5, G1 arrest, and apoptosis; orally active.
