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Chemical Structure : KW-2581
Catalog No.: PC-61434Not For Human Use, Lab Use Only.
A novel potent, irreversible and orally active inhibitor of steroid sulfatase (STS) with IC50 of 13 nM in ZR-75-1 cells.
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A novel potent, irreversible and orally active inhibitor of steroid sulfatase (STS) with IC50 of 13 nM in ZR-75-1 cells; inhibits the E1S-stimulated growth of ZR-75-1 cells, reduces the expression of E1S-induced progesterone receptors at concentrations as low as 0.1 nM; causes tumor shrinkage in a mouse xenograft model.
Breast Cancer
Discontinued
| M.Wt | 460.633 | |
| Formula | C25H36N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ishida H, et al. Breast Cancer Res Treat. 2007 Aug;104(2):211-9.
2. Ishida H, et al. Breast Cancer Res Treat. 2007 Dec;106(2):215-27
3. Ishida H, et al. J Steroid Biochem Mol Biol. 2008 Jan;108(1-2):17-22.
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