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KW-2581

Chemical Structure : KW-2581

CAS No.: 284045-56-3

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KW-2581 (KW2581)

Catalog No.: PC-61434Not For Human Use, Lab Use Only.

KW-2581 is a potent, irreversible and orally active inhibitor of steroid sulfatase (STS) with IC50 of 13 nM in ZR-75-1 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KW-2581 is a potent, irreversible and orally active inhibitor of steroid sulfatase (STS) with IC50 of 13 nM in ZR-75-1 cells.
    KW-2581 inhibits the E1S-stimulated growth of ZR-75-1 cells, reduces the expression of E1S-induced progesterone receptors at concentrations as low as 0.1 nM.
    KW-2581 causes tumor shrinkage in a mouse xenograft model.

    Physicochemical Properties

    M.Wt 460.633
    Formula C25H36N2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [(8S,9S,13S,14S)-17-[di(propan-2-yl)carbamoyl]-13-methyl-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-3-yl] sulfamate

    References

    1. Ishida H, et al. Breast Cancer Res Treat. 2007 Aug;104(2):211-9.

    2. Ishida H, et al. Breast Cancer Res Treat. 2007 Dec;106(2):215-27

    3. Ishida H, et al. J Steroid Biochem Mol Biol. 2008 Jan;108(1-2):17-22.

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