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You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-Src-KX2-361
KX2-361

Chemical Structure : KX2-361

CAS No.: 897016-26-1

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KX2-361 (KX-2361, KX-02)

Catalog No.: PC-63531Not For Human Use, Lab Use Only.

KX2-361 (KX 02) is a potent, orally active dual Src signaling/tubulin polymerization inhibitor, KX2-361 is a non-ATP competitive Src inhibitor, demonstrates broad anti-tumor activity both in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KX2-361 (KX 02) is a potent, orally active dual Src signaling/tubulin polymerization inhibitor, KX2-361 is a non-ATP competitive Src inhibitor, demonstrates broad anti-tumor activity both in vitro and in vivo.
KX2-361 binds to tubulin and disrupts microtubule architecture in cells.
KX2-361 (200 nM) reduced autophosphorylation of Src at tyrosine 416, consistent with reduced Src signaling activity.
KX2-361 (5 µM) inhibits the in vitro assembly of tubulin polymers.
KX2-361 disrupts the microtubule network resulting in altered morphology, loss of microtubule integrity, and a general reduction in cell size in intact GL261 cells.
KX2‑361 promotes cell cycle arrest and apoptosis.
KX2‑361 significantly delays progression of orthotopic GL261 brain tumors and produces long‑term survival.

Physicochemical Properties

M.Wt 405.473
Formula C24H24FN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl)acetamide

References

1. Smolinski MP, et al. J Med Chem. 2018 Apr 17. doi: 10.1021/acs.jmedchem.8b00164.
2 Ciesielski MJ, et al. J Neurooncol. 2018 Dec;140(3):519-527.

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