Chemical Structure : KX2-391 dihydrochloride
CAS No.: 1038395-65-1
Catalog No.: PC-42538Not For Human Use, Lab Use Only.
Tirbanibulin (KX2-391 dihydrochloride) is a highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor.
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|---|---|---|---|
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| 25 mg | $128 | In stock | |
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	Tirbanibulin (KX2-391 dihydrochloride) is a highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor.
	KX2-391 inhibits c-Src kinase with GI50s of 1.34 uM and 2.30 μM in NIH3T3/c-Src527F and SYF/c-Src527F cells, respectively.
	KX2-391 causes microtubule disruption in tumor cells; orally active.
| M.Wt | 504.4486 | |
| Formula | C26H31Cl2N3O3 | |
| Appearance | Solid | |
| Storage | 
                            
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| Solubility | 
                             10 mM in DMSO  | 
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| Chemical Name/SMILES | 
                             2-Pyridineacetamide, 5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-, hydrochloride (1:2)  | 
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1. Fallah-Tafti A, et al. Eur J Med Chem. 2011 Oct;46(10):4853-8.
2. Anbalagan M, et al. Mol Cancer Ther. 2012 Sep;11(9):1936-47.
3. Liu T, et al. Clin Cancer Res. 2013 Dec 1;19(23):6532-43.

                
                
                
                
                
                
                
                
            
            
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