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KX2-391 mesylate

Chemical Structure : KX2-391 mesylate

CAS No.: 1080645-95-9

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KX2-391 mesylate (KX01 Mesylate)

Catalog No.: PC-42539Not For Human Use, Lab Use Only.

A highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor.

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10 mg $96 In stock
50 mg $376 In stock
100 mg $640 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor; inhibits c-Src kinase with GI50s of 1.34 uM and 2.30 μM in NIH3T3/c-Src527F and SYF/c-Src527F cells, respectively; causes microtubule disruption in tumor cells; orally active.

Solid Tumors

Phase 2 Clinical

Physicochemical Properties

M.Wt 527.6324
Formula C27H33N3O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 57 mg/mL
Chemical Name/SMILES

2-Pyridineacetamide, 5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-, methanesulfonate (1:1)

References

1. Fallah-Tafti A, et al. Eur J Med Chem. 2011 Oct;46(10):4853-8.

2. Anbalagan M, et al. Mol Cancer Ther. 2012 Sep;11(9):1936-47.

3. Liu T, et al. Clin Cancer Res. 2013 Dec 1;19(23):6532-43.

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