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Chemical Structure : KX2-391 mesylate
CAS No.: 1080645-95-9
Catalog No.: PC-42539Not For Human Use, Lab Use Only.
A highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $96 | In stock | |
| 50 mg | $376 | In stock | |
| 100 mg | $640 | In stock |
Bulk size, bulk discount!
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A highly selective, non-ATP competitive substrate-pocket-directed Src/pretubulin inhibitor; inhibits c-Src kinase with GI50s of 1.34 uM and 2.30 μM in NIH3T3/c-Src527F and SYF/c-Src527F cells, respectively; causes microtubule disruption in tumor cells; orally active.
Solid Tumors
Phase 2 Clinical
| M.Wt | 527.6324 | |
| Formula | C27H33N3O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 57 mg/mL |
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| Chemical Name/SMILES |
2-Pyridineacetamide, 5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-, methanesulfonate (1:1) |
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1. Fallah-Tafti A, et al. Eur J Med Chem. 2011 Oct;46(10):4853-8.
2. Anbalagan M, et al. Mol Cancer Ther. 2012 Sep;11(9):1936-47.
3. Liu T, et al. Clin Cancer Res. 2013 Dec 1;19(23):6532-43.
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