KY-05009 (KY05009) is a potent, ATP-competitive inhibitor of Traf2- and Nck-interacting kinase (TNIK) with Ki of 100 nM.
KY-05009 (KY05009) significantly and strongly inhibited the TGF-β-activated EMT through the attenuation of Smad and non-Smad signaling pathways, including the Wnt, NF-κB, FAK-Src-paxillin-related focal adhesion, and MAP kinases (ERK and JNK) signaling pathways in A549 cells.
KY-05009 (KY05009) synergistically inhibited IL-6-stimulated proliferation and induced apoptosis through the inhibition of Wnt signaling in MM cells when combined Dovitinib.
