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Chemical Structure : KY-05009
CAS No.: 1228280-29-2
Catalog No.: PC-36009Not For Human Use, Lab Use Only.
KY-05009 (KY05009) is a potent, ATP-competitive inhibitor of Traf2- and Nck-interacting kinase (TNIK) with Ki of 100 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $318 | In stock | |
| 100 mg | Get quote |
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KY-05009 (KY05009) is a potent, ATP-competitive inhibitor of Traf2- and Nck-interacting kinase (TNIK) with Ki of 100 nM.
KY-05009 (KY05009) significantly and strongly inhibited the TGF-β-activated EMT through the attenuation of Smad and non-Smad signaling pathways, including the Wnt, NF-κB, FAK-Src-paxillin-related focal adhesion, and MAP kinases (ERK and JNK) signaling pathways in A549 cells.
KY-05009 (KY05009) synergistically inhibited IL-6-stimulated proliferation and induced apoptosis through the inhibition of Wnt signaling in MM cells when combined Dovitinib.
| M.Wt | 352.412 | |
| Formula | C18H16N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide |
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1. Kim J, et al. PLoS One. 2014 Oct 22;9(10):e110180.
2. Lee Y, et al. Oncotarget. 2017 Jun 20;8(25):41091-41101.
3. Yamada T, et al. (2010) TNIK inhibitor and its use. US2010/0216795.
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