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Chemical Structure : KY386
Catalog No.: PC-21245Not For Human Use, Lab Use Only.
KY386 is a potent, selective inhibitor of RNA helicase DHX33 with IC50 of 19 nM.
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KY386 is a potent, selective inhibitor of RNA helicase DHX33 with IC50 of 19 nM.
KY386 potently inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.
KY386 has little inhibitory effect toward other RNA helicases include DDX6, DHX15, DDX21, DHX32, DHX35, DHX40 and DDX59.
KY386 shows potent anti-cancer activity and moderate metabolic stability.
| M.Wt | 405.48 | |
| Formula | C21H19N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang Y, et al. Bioorg Med Chem Lett. 2023 Oct 12:129505.
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