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KY386

Chemical Structure : KY386

CAS No.: 2787598-01-8

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KY386 (KY 386, KY-386)

Catalog No.: PC-21245Not For Human Use, Lab Use Only.

KY386 is a potent, selective inhibitor of RNA helicase DHX33 with IC50 of 19 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KY386 is a potent, selective inhibitor of RNA helicase DHX33 with IC50 of 19 nM.
KY386 potently inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.
KY386 has little inhibitory effect toward other RNA helicases include DDX6, DHX15, DDX21, DHX32, DHX35, DHX40 and DDX59.
KY386 shows potent anti-cancer activity and moderate metabolic stability.

Physicochemical Properties

M.Wt 405.48
Formula C21H19N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3-cyano-5-methylthiophen-2-yl)-N-(6-methoxy-1H-benzo[d]imidazol-2-yl)-2,5-dimethyl-1H-pyrrole-3-carboxamide

References

1. Wang Y, et al. Bioorg Med Chem Lett. 2023 Oct 12:129505.

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