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KYT-1

Chemical Structure : KYT-1

CAS No.: 241825-16-1

KYT-1 (Carbobenzoxy-Lys-Arg-CO-Lys-N-(CH2)2)

Catalog No.: PC-72420Not For Human Use, Lab Use Only.

KYT-1 is a potent, selective inhibitor of P. gingivalis virulence factor Arg-gingipain (Rgp) with Ki 40 nM (RgpA/B).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KYT-1 is a potent, selective inhibitor of P. gingivalis virulence factor Arg-gingipain (Rgp) with Ki 40 nM (RgpA/B).
    KYT-1 showed significant inhibitory effects on SMC proliferation stimulated by Porphyromonas gingivalis.

    Physicochemical Properties

    M.Wt 619.768
    Formula C29H49N9O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    Chemical Name/SMILES

    benzyl ((S)-6-amino-1-(((S)-1-(((S)-6-amino-1-(dimethylamino)-1-oxohexan-2-yl)amino)-6-guanidino-1,2-dioxohexan-3-yl)amino)-1-oxohexan-2-yl)carbamate

    References

    1. Kadowaki T, et al. Mol Pharmacol. 2004 Dec;66(6):1599-606.

    2. Hosn KN, et al. Clin Exp Dent Res. 2015 Oct 27;1(1):18-25.

    3. Inaba H, et al. J Periodontol. 2011 Nov;82(11):1616-22.

    4. Cao C, et al. Int J Clin Exp Med. 2015 Oct 15;8(10):18327-34.

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