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Chemical Structure : Kaitocephalin
Catalog No.: PC-61708Not For Human Use, Lab Use Only.
Kaitocephalin (PF 1191) is a non-selective ionotropic glutamate receptor (iGluR) antagonist, the first discovered natural toxin with protective properties against excitotoxic-death of cultured neurons induced by NMDA or AMPA/kainate receptors.
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Kaitocephalin (PF 1191) is a non-selective ionotropic glutamate receptor (iGluR) antagonist, the first discovered natural toxin with protective properties against excitotoxic-death of cultured neurons induced by NMDA or AMPA/kainate receptors; a more potent antagonist of NMDA receptors (IC50= 75 nM) than of AMPA receptors from cerebral cortex (IC50=242 nM) and from homomeric GluR3 subunits (IC50=502 nM); shows neuroprotective properties, and protects neurons by inhibiting excitotoxicity.
| M.Wt | 494.28 | |
| Formula | C18H21Cl2N3O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ma D, et al. J Am Chem Soc. 2001 Oct 3;123(39):9706-7.
2. Shin-Ya K, et al. Biosci Biotechnol Biochem. 2005 May;69(5):867-72.
3. Limon A, et al. ACS Chem Neurosci. 2010 Mar 17;1(3):175-181.
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