Catalog No.: PC-26809Not For Human Use, Lab Use Only.
Kartogenin (KGN) is a small molecule stimulator of collagen synthesis of mesenchymal stem cells (MSCs), binds filamin A and disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program promotes chondrocyte differentiation with EC50 of 100 nM.
Kartogenin (KGN) is a small molecule stimulator of collagen synthesis of mesenchymal stem cells (MSCs), binds filamin A and disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program promotes chondrocyte differentiation with EC50 of 100 nM. Kartogenin (KGN) shows chondroprotective effects in vitro and in osteoarthritis (OA) animal models. Kartogenin (KGN) stimulate collagen synthesis of mesenchymal stem cells (MSCs). Kartogenin (KGN) also is a potent stimulator of limb skeletal growth, facilitates joint formation by promoting interzone compaction and lubricin/Prg4 expression, and stimulates the activity of key signaling factors, including TGFβ superfamily members.
Physicochemical Properties
M.Wt
317.34
Formula
C20H15NO3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-([1,1'-Biphenyl]-4-ylcarbamoyl)benzoic acid
References
1. Johnson K, et al. Science. 2012 May 11;336(6082):717-21.
2. Wang J, et al. Biochem Biophys Res Commun. 2014 Jul 18;450(1):568-74.
3. Decker RS, et al. Dev Biol. 2014 Nov 15;395(2):255-67.
