Ketotifen | PDE8B inhibitor | Probechem Biochemicals

Chemical Structure : Ketotifen

CAS No.: 34580-13-7

Ketotifen (HC 20-511)

Catalog No.: PC-23486Not For Human Use, Lab Use Only.

Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer, also is a PDE8B inhibitor.

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100 mg	$48	In stock
500 mg	$98	In stock
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Biological Activity

Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer, also is a PDE8B inhibitor.
Ketotifen blocks 6-phosphogluconate dehydrogenase (PGD) in vitro.
Ketotifen also has antiviral activity against SARS-CoV-2 and influenza virus.
Ketotifen reduces activation of primordial follicles in mouse ovaries.

Physicochemical Properties

M.Wt	309.43
Formula	C19H19NOS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-Methylpiperidin-4-ylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one

References

1. Madsen JF, et al. Mol Reprod Dev. 2023 Jun;90(6):378-388.

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Ketotifen (HC 20-511)

Biological Activity

Physicochemical Properties

References

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