Ki20227 |CAS:623142-96-1 Probechem Biochemicals

Chemical Structure : Ki20227

CAS No.: 623142-96-1

Ki20227 (Ki 20227;Ki-20227)

Catalog No.: PC-42568Not For Human Use, Lab Use Only.

Ki20227 is a potent, selective, orally active c-Fms inhibitor with IC50 of 2 nM.

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$178	In stock
25 mg	$298	In stock
50 mg	$488	In stock
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Biological Activity

Ki20227 is a potent, selective, orally active c-Fms (CSF1R) inhibitor with IC50 of 2 nM.
Ki20227 weakly inhibits KDR, c-Kit, and PDGFRβ with IC50 of 12, 451, and 217 nM, respectively, no activty against Flt-3, c-Src, Fyn, EGFR, FGFR2, Met, Btk, PKA, and PKCα (IC50>1,000 nM).
Ki20227 inhibits the M-CSF-dependent cell growth, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.

Physicochemical Properties

M.Wt	480.5362
Formula	C24H24N4O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: 7.2 mg/mL
Chemical Name/SMILES	Urea, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]-

References

1. Ohno H, et al. Mol Cancer Ther. 2006 Nov;5(11):2634-43.

2. Ohno H, et al. Eur J Immunol. 2008 Jan;38(1):283-91.

3. Uemura Y, et al. J Neuroimmunol. 2008 Mar;195(1-2):73-80.

Ki20227 (Ki 20227;Ki-20227)

Biological Activity

Physicochemical Properties

References

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