Ki26894 | TβR-I kinase inhibitor | Probechem Biochemicals

Chemical Structure : Ki26894

Ki26894 (Ki 26894)

Catalog No.: PC-49752Not For Human Use, Lab Use Only.

Ki26894 (Ki 26894) is a small molecule TGF-beta type I receptor (TbetaR-I) kinase inhibitor, inhibits TGF-β-induced transcriptional activation in MDA-231-D-TβFluc/Rluc cells with IC50 of 0.49 uM.

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Biological Activity

Ki26894 (Ki 26894) is a small molecule TGF-beta type I receptor (TbetaR-I) kinase inhibitor, inhibits TGF-β-induced transcriptional activation in MDA-231-D-TβFluc/Rluc cells with IC50 of 0.49 uM.
Ki26894 reduces the level of TGF-β-induced transcription to basal level at 3 uM in MDA-231-D-TβFluc/Rluc cells.
Ki26894 decreases motility and invasion of MDA-231-D cells induced by TGF-β.
Ki26894 inhibits TGF-β-induced transcription of PAI-1, PTHrP and IL-11 in MDA-231-D cells.
Ki26894 prevents metastasis of MDA-231-D cells and prolongs the survival of MDA-231-D-bearing mice.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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Ki26894 (Ki 26894)

Biological Activity

Physicochemical Properties

References

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