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Chemical Structure : L-054,264
CAS No.: 208706-12-1
Catalog No.: PC-23186Not For Human Use, Lab Use Only.
L-054,264 is a potent, selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist with Ki of 1.6 nM, >1000-fold selective over other somatostatin receptor subtypes.
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|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
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L-054,264 is a potent, selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist with Ki of 1.6 nM, >1000-fold selective over other somatostatin receptor subtypes.
L-054,264 shows full agonism on sst2 in the inhibition of forskolin-stimulated accumulation of cAMP with an IC50 of 2 nM.
L-054,264 also inhibits the release of growth hormone in the rat pituitary assay with IC50 of 6 nM.
| M.Wt | 539.72 | |
| Formula | C33H41N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(1R)-2-[[[3-(Aminomethyl)cyclohexyl]methyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]spiro[1H-indene-1,4′-piperidine]-1′-carboxamide |
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1. Yang L, et al. J Med Chem. 1998 Jun 18;41(13):2175-9.
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