L-161240 | LpxC inhibitor | Probechem Biochemicals

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Chemical Structure : L-161240

L-161240 (L-161,240)

Catalog No.: PC-26545Not For Human Use, Lab Use Only.

L-161240 (L-161,240) is an antibacterial agent that inhibit lipid A biosynthesis, inhibits LpxC with IC50 of 26 nM and inhibition constant (Ki) of 50 nM, displays MIC of about 1 ug /mL against Escherichia coli.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	308.33
Formula	C15H20N2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(3,4-dimethoxy-5-propylphenyl)-N-hydroxy-4,5-dihydrooxazole-4-carboxamide

References

1. Onishi HR, et al. Science. 1996 Nov 8;274(5289):980-2.

2. Clements JM,et al. Antimicrob Agents Chemother. 2002 Jun;46(6):1793-9.

3. Chen MH, et al. Bioorg Med Chem Lett. 1999 Feb 8;9(3):313-8.

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L-161240 (L-161,240)

Biological Activity

Physicochemical Properties

References

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