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Chemical Structure : L-364373
Catalog No.: PC-63221Not For Human Use, Lab Use Only.
L-364373 (R-L3) is a stereospecific activator of cardiac slowly activating delayed rectifier K+ current (IKs) and KV7.1 (KCNQ1) channels.
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L-364373 (R-L3) is a stereospecific activator of cardiac slowly activating delayed rectifier K+ current (IKs) and KV7.1 (KCNQ1) channels.
L-364373 significantly decreases APD50 and APD90 without significantly affecting other AP parameters at 0.1-1 uM, slows the rate of IKs deactivation and shifted the half-point of the isochronal (7.5 sec) activation curve for IKs by -16 mV at 0.1 uM and -24 mV at 1 uM.
L-364373 rescues pharmacologically induced long QT type 2 in isolated guinea pig cardiomyocytes.
| M.Wt | 397.453 | |
| Formula | C25H20FN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Salata JJ, et al. Mol Pharmacol. 1998 Jul;54(1):220-30.
2. Magyar J, et al. Naunyn Schmiedebergs Arch Pharmacol.
3. Nissen JD, et al. J Cardiovasc Pharmacol. 2009 Aug;54(2):169-77.
4. Corici C, et al. Can J Physiol Pharmacol. 2013 Aug;91(8):586-92.
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