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Chemical Structure : L-365260
Catalog No.: PC-70239Not For Human Use, Lab Use Only.
L-365260 (L365260) is a potent, selective, orally active cholecystokinin receptor 2 (CCK2) antagonist with IC50 of 2 nM.
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L-365260 (L365260) is a potent, selective, orally active cholecystokinin receptor 2 (CCK2) antagonist with IC50 of 2 nM.
L-365260 displays >100-fold selecitvity over CCK1.
L-365260 antagonizes gastrin-stimulated acid secretion in mice (ED50 = 0.03 mg/kg), does not affect basal acid secretion and did not antagonize histamine- or carbachol-stimulated acid secretion.
| M.Wt | 398.46 | |
| Formula | C24H22N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kopin AS, et al. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5525-30.
2. Bock MG, et al. J Med Chem. 1989 Jan;32(1):13-6.
3. Lotti VJ, et al. Eur J Pharmacol. 1989 Mar 21;162(2):273-80.
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