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L-365260

Chemical Structure : L-365260

CAS No.: 118101-09-0

L-365260 (L 365260;L365260)

Catalog No.: PC-70239Not For Human Use, Lab Use Only.

L-365260 (L365260) is a potent, selective, orally active cholecystokinin receptor 2 (CCK2) antagonist with IC50 of 2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    L-365260 (L365260) is a potent, selective, orally active cholecystokinin receptor 2 (CCK2) antagonist with IC50 of 2 nM.
    L-365260 displays >100-fold selecitvity over CCK1.
    L-365260 antagonizes gastrin-stimulated acid secretion in mice (ED50 = 0.03 mg/kg), does not affect basal acid secretion and did not antagonize histamine- or carbachol-stimulated acid secretion.

    Physicochemical Properties

    M.Wt 398.46
    Formula C24H22N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea

    References

    1. Kopin AS, et al. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5525-30.

    2. Bock MG, et al. J Med Chem. 1989 Jan;32(1):13-6.

    3. Lotti VJ, et al. Eur J Pharmacol. 1989 Mar 21;162(2):273-80.

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