Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Wnt/Notch/Hedgehog-γ-secretase-L-685458
L-685458

Chemical Structure : L-685458

CAS No.: 292632-98-5

Add to Favorites

L-685458 (L-685,458;L685458;L 685458)

Catalog No.: PC-45626Not For Human Use, Lab Use Only.

L-685458 (L-685,458) is a potent inhibitor of amyloid β-protein precursor gamma-secretase activity (IC50=14 nM).

Packing Price Stock Quantity
5 mg $388 In stock
10 mg $598 In stock
25 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

L-685458 (L-685,458) is a potent inhibitor of amyloid β-protein precursor gamma-secretase activity (IC50=14 nM).
L-685458 shows similar potency for inhibition of A beta(42) and A beta(40) peptides.

Physicochemical Properties

M.Wt 672.8534
Formula C39H52N4O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL
Chemical Name/SMILES

L-Phenylalaninamide, N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-

References

1. Shearman MS, et al. Biochemistry. 2000 Aug 1;39(30):8698-704.

2. Pozdnyakov N, et al. J Biol Chem. 2013 Apr 5;288(14):9710-20.

3. Liu F, et al. Eur J Neurosci. 2013 May;37(10):1714-25.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: