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L-701324

Chemical Structure : L-701324

CAS No.: 142326-59-8

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L-701324 (L-701,324, L701324)

Catalog No.: PC-45532Not For Human Use, Lab Use Only.

L-701324 (L-701,324) is a potent, orally active antagonist at the glycine modulatory site on NMDA receptor with IC50 of 2 nM.

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10 mg $118 In stock
25 mg $198 In stock
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100 mg $478 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

L-701324 (L-701,324) is a potent, orally active antagonist at the glycine modulatory site on NMDA receptor with IC50 of 2 nM.
L-701324 is a potent, p.o. active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents.

Physicochemical Properties

M.Wt 363.7938
Formula C21H14ClNO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 34 mg/mL
Chemical Name/SMILES

2(1H)-Quinolinone, 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-

References

1. Kulagowski JJ, et al. J Med Chem. 1994 May 13;37(10):1402-5.

2. Bristow LJ, et al. J Pharmacol Exp Ther. 1996 Nov;279(2):492-501.

3. Hutson PH, et al. Eur J Pharmacol. 1997 May 20;326(2-3):127-32.

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