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Chemical Structure : L-733060
Catalog No.: PC-70193Not For Human Use, Lab Use Only.
L-733060 is an orally active, non-peptide, selective antagonist for the NK1 receptor with Ki of 0.8 nM.
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L-733060 is an orally active, non-peptide, selective antagonist for the NK1 receptor with Ki of 0.8 nM.
L-733060 inhibits neurogenic plasma extravasation in rat dura produced by electrical stimulation of trigeminal nerves with ID50 of 212 mg/kg, i.v.
L-733060 shows no effect on mean arterial blood pressure or heart rate in conscious or anaesthetised rats.
| M.Wt | 403.361 | |
| Formula | C20H19F6NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Seabrook GR, et al. Eur J Pharmacol. 1996 Dec 12;317(1):129-35.
2. Rupniak NM, et al. Pain. 1996 Sep;67(1):189-95.
3. Rupniak NM, et al. Neuropharmacology. 2000 Jun 8;39(8):1413-21.
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