L-783277 |CAS:791807-02-8 Probechem Biochemicals

Chemical Structure : L-783277

L-783277 (L 783277;L783277)

Catalog No.: PC-60915Not For Human Use, Lab Use Only.

L-783277 is a resorcylic lactone type covalent kinase inhibitor that inhibits ALK1 with IC50 of 125 nM, also inhibits FLT3, VEGFR2, VEGFR3, MEK2 with IC50 of 1-10 nM.

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Biological Activity

L-783277 is a resorcylic lactone type covalent kinase inhibitor that inhibits ALK1 with IC50 of 125 nM, also inhibits FLT3, VEGFR2, VEGFR3, MEK2 with IC50 of 1-10 nM.

Physicochemical Properties

M.Wt	364.39
Formula	C19H24O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,5Z,8S,9S)-3,4,9,10,11,12-Hexahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

References

1. Liniger M, et al. ACS Med Chem Lett. 2010 Oct 20;2(1):22-7.

2. Cho H, et al. J Med Chem. 2017 Feb 23;60(4):1495-1508.

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L-783277 (L 783277;L783277)

Biological Activity

Physicochemical Properties

References

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