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L-NAME hydrochloride

Chemical Structure : L-NAME hydrochloride

CAS No.: 51298-62-5

L-NAME hydrochloride (NG-Nitroarginine methyl ester hydrochloride)

Catalog No.: PC-45544Not For Human Use, Lab Use Only.

L-NAME hydrochloride is a widely used inhibitor of NO synthase (NOS) with IC50 of 70 uM for purified brain NOS.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

L-NAME hydrochloride is a widely used inhibitor of NO synthase (NOS) with IC50 of 70 uM for purified brain NOS.
L-NAME hydrochloride inhibits cGMP formation in endothelial cells with an IC50 of 3.1 µM (in the presence of 30 µM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings.

Physicochemical Properties

M.Wt 269.686
Formula C7H16ClN5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: ≥ 32 mg/mL

Chemical Name/SMILES

L-Ornithine, N5-[imino(nitroamino)methyl]-, methyl ester, hydrochloride (1:1)

References

1. Pfeiffer S, et al. Br J Pharmacol. 1996 Jul;118(6):1433-40.

2. Lo HC, et al. PLoS One. 2016 Mar 23;11(3):e0151973.

3. Xiao H, et al. Oncotarget. 2017 May 2;8(18):29976-29983.

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