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L 873724

Chemical Structure : L 873724

CAS No.: 603139-12-4

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L 873724 (L873724, L-873724)

Catalog No.: PC-62964Not For Human Use, Lab Use Only.

L 873724 is a potent and selective non-basic cathepsin K inhibitor with IC50 of 0.2 nM, shows no significant potency against Cat B, L, and S (IC50= 5239, 264, and 178 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    L 873724 is a potent and selective non-basic cathepsin K inhibitor with IC50 of 0.2 nM, shows no significant potency against Cat B, L, and S (IC50= 5239, 264, and 178 nM).
    L 873724 demonstrates excellent pharmacokinetics and efficacy in an ovariectomized (OVX) rhesus monkey model.

    Physicochemical Properties

    M.Wt 481.534
    Formula C23H26F3N3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S)-N-(cyanomethyl)-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide

    References

    1. Li CS, et al. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1985-9.

    2. Desmarais S, et al. Mol Pharmacol. 2008 Jan;73(1):147-56.

    3. Pennypacker BL, et al. BMC Musculoskelet Disord. 2013 Dec 9;14:344.

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