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Chemical Structure : LAF389
Catalog No.: PC-63316Not For Human Use, Lab Use Only.
LAF389 is a potent methionine aminopeptidase (MetAP) inhibitor with IC50 of 800 nM for MetAP-2, inhibits both MetAP1 and 2, potently inhibits HUVEC proliferation with IC50 of 20 nM.
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LAF389 is a potent methionine aminopeptidase (MetAP) inhibitor with IC50 of 800 nM for MetAP-2, inhibits both MetAP1 and 2, potently inhibits HUVEC proliferation with IC50 of 20 nM.
LAF389 demonstrates both antiproliferative and antiangiogenetic properties, and preclinical investigations showed a broad antitumour activity.
| M.Wt | 498.617 | |
| Formula | C25H42N2O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kinder FR Jr, et al. J Med Chem. 2001 Oct 25;44(22):3692-9.
2. Towbin H, et al. J Biol Chem. 2003 Dec 26;278(52):52964-71.
3. Kim S, et al. Cancer Res. 2004 May 1;64(9):2984-7.
4. Dumez H, et al. Anticancer Drugs. 2007 Feb;18(2):219-25.
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