LAG-3 PROTAC-1

Chemical Structure : LAG-3 PROTAC-1

Catalog No.: PC-25871Not For Human Use, Lab Use Only.

LAG-3 PROTAC-1 is a potent, efficacious PROTAC) degrader of immune checkpoint receptor lymphocyte activation gene-3 (LAG-3) with DC50 of 0.27 uM in Raji-LAG3 cells (24 h).

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Biological Activity

LAG-3 PROTAC-1 is a potent, efficacious PROTAC) degrader of immune checkpoint receptor lymphocyte activation gene-3 (LAG-3) with DC50 of 0.27 uM in Raji-LAG3 cells (24 h).

Physicochemical Properties

M.Wt	608.70
Formula	C34H36N6O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S)-N-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)-4-phenyl-1-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide

References

1. Vázquez NG, et al. Bioorg Med Chem Lett. 2025 Oct 4;130:130428.

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LAG-3 PROTAC-1

Biological Activity

Physicochemical Properties

References

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