Chemical Structure : LAG-3 inhibitor 11
CAS No.:
LAG-3 inhibitor 11
Catalog No.: PC-25371Not For Human Use, Lab Use Only.
LAG-3 inhibitor 11 is a potent, small molecule LAG-3 inhibitor, binds LAG-3 with MST KD of 0.41 uM, demonstrates disruption of the LAG-3/MHC II interaction in a cellular assay with EC50 of 0.31 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LAG-3 inhibitor 11 is a potent, small molecule LAG-3 inhibitor, binds LAG-3 with MST KD of 0.41 uM, demonstrates disruption of the LAG-3/MHC II interaction in a cellular assay with EC50 of 0.31 uM.
LAG-3 inhibitor 11 (10 uM) induces a significant increase in IFN-γ secretion, mirroring the effect observed with relatlimab, in PBMCs cocultured with THP-1 AML cells.
LAG-3 inhibitor 11 (10 uM) enhances AML cell killing, effectively potentiates immune responses against AML.
LAG-3 inhibitor 11 activates immune effector responses across both hematological and epithelial cancer models.
Physicochemical Properties
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M.Wt
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447.58
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Formula
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C30H29N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(3R,4S)-N-([1,1'-biphenyl]-4-ylmethyl)-4-phenyl-1-(pyridin-2-ylmethyl)pyrrolidine-3-carboxamide
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References
1. Abdel-Rahman SA, et al. J Med Chem. 2025 Aug 20. doi: 10.1021/acs.jmedchem.5c00995.
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