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Chemical Structure : LAG-3 inhibitor SA-15-P
Catalog No.: PC-20828Not For Human Use, Lab Use Only.
LAG-3 inhibitor SA-15-P is a small molecule dual inhibitor of LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 of 4.21 and 6.52 uM, respectively.
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LAG-3 inhibitor SA-15-P is a small molecule dual inhibitor of LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 of 4.21 and 6.52 uM, respectively.
SA-15-P blocks LAG-3-mediated interactions in coculture cellular assays.
SA-15-P inhibits the interaction between both proteins expressed on cell surfaces with IC50 of 6.95 uM.
SA-15-P is a cell-active dual inhibitor of the interactions of LAG-3 with major histocompatibility complex (MHC) class II and fibrinogen-like protein 1 (FGL1).
| M.Wt | 428.49 | |
| Formula | C26H24N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Somaya A Abdel-Rahman, et al. ACS Med Chem Lett. 2023 Apr 11;14(5):629-635.
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