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LAGi-DEL

Chemical Structure : LAGi-DEL

CAS No.:

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LAGi-DEL

Catalog No.: PC-25821Not For Human Use, Lab Use Only.

LAGi-DEL is a potent small molecule LAG-3 inhibitor, binds directly to LAG-3 with Kd value of 97 nM (SPR) and 271 nM (MST), disrupts the LAG-3/MHC-II interaction with EC50 of 138 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LAGi-DEL is a potent small molecule LAG-3 inhibitor, binds directly to LAG-3 with Kd value of 97 nM (SPR) and 271 nM (MST), disrupts the LAG-3/MHC-II interaction with EC50 of 138 nM.
LAGi-DEL (10 μM) significantly increased IFN-γ secretion in PBMCs upon co-culturing with THP-1 cells, suggesting restored T cell activation.
LAGi-DEL enhances tumor cell killing in a dose-dependent manner.

Physicochemical Properties

M.Wt 530.60
Formula C28H26N4O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-6-(benzo[b]thiophen-7-yl)-N-(1-(3,5-dimethoxyphenyl)-3-(methylamino)-3-oxopropyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxamide

References

1. Nada H, et al. Eur J Med Chem. 2026 Jan 5;301:118204.

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