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Chemical Structure : LAKI
Catalog No.: PC-20745Not For Human Use, Lab Use Only.
LAKI (Light Activated K+ channel Inhibitor) is a specific photoswitchable inhibitor of the pain-related two-pore-domain potassium (K2P) TREK and TRESK channels.
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LAKI (Light Activated K+ channel Inhibitor) is a specific photoswitchable inhibitor of the pain-related two-pore-domain potassium (K2P) TREK and TRESK channels.
In the dark or ambient light, LAKI is inactive. However, alternating transdermal illumination at 365 nm and 480 nm reversibly blocks and unblocks TREK/TRESK current in nociceptors, enabling rapid control of pain and nociception in intact and freely moving mice and nematode.
LAKI has an IC50 of 2.45, 1.79, and 1.75 µM for TREK1, TREK2, and TRESK respectively.
LAKI enables optical control of potassium currents in native nociceptors through an endogenous TREK1, TREK2 and TRESK photoblock. LAKI controls pain behavior in freely moving mice.
| M.Wt | 345.40 | |
| Formula | C21H19N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Landra-Willm A, et al. Nat Commun. 2023 Mar 1;14(1):1160.
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