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LAS191954

Chemical Structure : LAS191954

CAS No.: 1403947-26-1

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LAS191954 (LAS-191954;LAS 191954)

Catalog No.: PC-60447Not For Human Use, Lab Use Only.

LAS191954 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LAS191954 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM.
    LAS191954 displays highest selectivity versus PI3Kα (IC50=8.2 uM) and the lowest versus PI3Kγ and PI3Kβ (IC50=72 and 94 nM respectively).
    LAS191954 inhibits pAkt (Thr308) produced through PI3K with IC50 of 7.8 nM in THP-1 cells, inhibits IL2 production with an ID50 of 0.13 mg/kg in rat model of con A.

    Physicochemical Properties

    M.Wt 397.402
    Formula C20H15N9O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(1-((6-amino-5-cyanopyrimidin-4-yl)amino)ethyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile

    References

    1. Erra M, et al. ACS Med Chem Lett. 2016 Nov 30;8(1):118-123.

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