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LB-205

Chemical Structure : LB-205

CAS No.: 1113025-86-7

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LB-205 (LB 205;LB205)

Catalog No.: PC-70352Not For Human Use, Lab Use Only.

LB-205 is a Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LB-205 is a Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo.
    LB-205 significantly enhances the migration of astrocytes and accelerates wound repair more effectively than SAHA and VPA.
    LB-205 up-regulates the expression of NGF, phospho-TrkA, p-AKT, NF-κB, and Bcl-2, while down-regulates the expression of p75 NTR, phospho-JNK, and Bax.

    Physicochemical Properties

    M.Wt 343.445
    Formula C18H21N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-mercapto-N-(6-oxo-6-(pyridin-3-ylamino)hexyl)benzamide

    References

    1. Lu J, et al. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21200-5.

    2. Lu J, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52.

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