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LB42908

Chemical Structure : LB42908

CAS No.: 226927-89-5

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LB42908 (LB 42908;LB-42908)

Catalog No.: PC-63362Not For Human Use, Lab Use Only.

LB42908 is a highly potent, selective, orally active inhibitor of Ras farnesyltransferase (FTase) with IC50 of 0.9 nM against H-Ras and 2.4 nM against K-Ras..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LB42908 is a highly potent, selective, orally active inhibitor of Ras farnesyltransferase (FTase) with IC50 of 0.9 nM against H-Ras and 2.4 nM against K-Ras.

    Physicochemical Properties

    M.Wt 533.62
    Formula C32H31N5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1-((1-(benzo[d][1,3]dioxol-5-ylmethyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(4-methylpiperazin-1-yl)methanone

    References

    1. Lee H, et al. Bioorg Med Chem Lett. 2001 Dec 3;11(23):3069-72.

    2. Kim HJ, et al. Bioorg Med Chem Lett. 2012 May 1;22(9):3067-71.

    3. Kim HS, et la. Toxicol Appl Pharmacol. 2006 Sep 15;215(3):317-29.

    4. Lee SK, et al. Int J Cancer. 2006 May 1;118(9):2172-81.

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