Chemical Structure : LC-TEAD01
CAS No.:
LC-TEAD01
Catalog No.: PC-26706Not For Human Use, Lab Use Only.
LC-TEAD01 is a potent, selective and covalent TEAD inhibitor with IC50 of 116 nM for TEAD1, inhibits TEAD1-YAP peptide binding with IC50 of 48.29 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
LC-TEAD01 is a potent, selective and covalent TEAD inhibitor with IC50 of 116 nM for TEAD1, inhibits TEAD1-YAP peptide binding with IC50 of 48.29 nM.
LC-TEAD01 exhibits cellular proliferation activity in the NCI-H226 cell line with IC50 of 618 nM.
LC-TEAD01 covalently binds to the conserved palmitoylation site (Cys359) of TEAD1 ipid pocket (LP).
LC-TEAD01 is a pan-TEAD inhibitor that can bind to all four TEAD isoform proteins.
LC-TEAD01 shows effective suppression of TEAD-dependent transcriptional activity in transfected HEK-293T cells.
LC-TEAD01 (30 and 50 mg/kg, qd, i.p.) demonstrates vivo antitumor efficacy of LC-TEAD01 in an NCI-H226 xenograft model in nude mice.
Physicochemical Properties
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M.Wt
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322.38
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Formula
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C14H18N4O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((1-(4-Propoxyphenyl)-1H-1,2,3-triazol-4-yl)methyl)ethenesulfonamide
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References
1. Yuhui Miao, et al. J Med Chem. 2026 May 5. doi: 10.1021/acs.jmedchem.6c00104.
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