LCL204 | NMT1 inhibitor | Probechem Biochemicals

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Chemical Structure : LCL204

LCL204 (LCL 204, LCL-204)

Catalog No.: PC-61226Not For Human Use, Lab Use Only.

LCL204 is a small molecule that inhibits N-myristoyltransferase (NMT1) with IC50 of 8.7 uM, 10-fold enhanced inhibitory potency than LCL4.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LCL204 is a small molecule that inhibits N-myristoyltransferase (NMT1) with IC50 of 8.7 uM, 10-fold enhanced inhibitory potency than LCL4.
LCL204 blocks Src myristoylation and Src localization to the cytoplasmic membrane.
LCL204 attenuates Src-mediated oncogenic signaling, suppresses cell-cycle progression, proliferation, and malignant growth of prostate cancer cells.

Physicochemical Properties

M.Wt	408.583
Formula	C23H40N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-1-(4-nitrophenyl)-2-(tetradecylamino)propane-1,3-diol

References

1. Kim S, et al. Cancer Res. 2017 Dec 15;77(24):6950-6962.

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LCL204 (LCL 204, LCL-204)

Biological Activity

Physicochemical Properties

References

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