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Chemical Structure : LD4172
Catalog No.: PC-22126Not For Human Use, Lab Use Only.
LD4172 is a first-in-class RIPK1 PROTAC degrader with DC50 values of 4-400 nM in a panel of human and mouse cancer cell lines.
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LD4172 is a first-in-class RIPK1 PROTAC degrader with DC50 values of 4-400 nM in a panel of human and mouse cancer cell lines.
LD4172 is a potent RIPK1 degrader with rapid and sustained effects in vitro.
LD4172 (1 uM) acheives >90% of RIPK1 degradation within 2 and 4 h in Jurkat and B16F10 cells, respectively.
LD4172 sensitizes B16F10 cells to TNFα-mediated apoptosis.
LD4172 induces immunogenic cell death (ICD) and enriches tumor-infiltrating lymphocytes and substantially sensitizes the tumors to anti-PD1 therapy.
| M.Wt | 1149.39 | |
| Formula | C61H75F3N10O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xin Yu, et al. bioRxiv. 2024 Mar 29:2024.03.25.586133.
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