LDC0496 | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : LDC0496

LDC0496 (LDC-0496)

Catalog No.: PC-38641Not For Human Use, Lab Use Only.

LDC0496 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome.

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Biological Activity

LDC0496 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome.

Physicochemical Properties

M.Wt	537.664
Formula	C32H35N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	isopropyl 3-(3-acrylamido-4-methylphenyl)-2-(4-(4-methylpiperazin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

References

1. Jonas Lategahn, et al. J Med Chem. 2022 Apr 29. doi: 10.1021/acs.jmedchem.1c02080.

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LDC0496 (LDC-0496)

Biological Activity

Physicochemical Properties

References

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