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Chemical Structure : LDC1267
CAS No.: 1361030-48-9
Catalog No.: PC-43061Not For Human Use, Lab Use Only.
LDC1267 is a potent, highly selective TAM receptor (Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3, Axl and Mer, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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LDC1267 is a potent, highly selective TAM receptor (Tyro3, Axl and Mer) kinase inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3, Axl and Mer, respectively.
LDC1267 displays lower activity against Met, Aurora B, Lck, Src, and CDK8.
LDC1267 abolishes the inhibitory effects of Gas6 stimulation in NK cells, moderately affects cell proliferation in 11 of 95 different cell lines with IC50 of >5 uM.
LDC1267 efficiently enhances anti-metastatic NK cell activity, and rejects tumor metastases without serious cytotoxicity (20 mg/kg, i.p.).
| M.Wt | 560.548 | |
| Formula | C30H26F2N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 42 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)- |
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1. Paolino M, et al. Nature. 2014 Mar 27;507(7493):508-12.
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