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LDD1937

Chemical Structure : LDD1937

CAS No.: 2319608-75-6

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LDD1937 (LDD 1937;LDD-1937)

Catalog No.: PC-63548Not For Human Use, Lab Use Only.

LDD1937 is a selective, potent FLT3 inhibitor with IC50 of 3 nM, displays >170-fold selectivity over JAK2/3, c-MET, IRAK-4.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    LDD1937 is a selective, potent FLT3 inhibitor with IC50 of 3 nM, displays >170-fold selectivity over JAK2/3, c-MET, IRAK-4.
    LDD1937 selectively inhibits the growth of MV-4-11 cells (GI50=1 nM) and induces apoptotic cell death, causes cell cycle arrest at the G2/M phase and increases the cell population at the sub-G1 phase.
    LDD1937 significantly reduces phosphorylation of STAT5, demonstrates in vivo anti-tumor effect in MV-4-11 xenograft models.

    Physicochemical Properties

    M.Wt 520.411
    Formula C24H27Cl2N5O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl (2Z,3E)-2'-oxo-3-((2-(piperazin-1-yl)ethoxy)imino)-[2,3'-biindolinylidene]-5'-carboxylate dihydrochloride

    References

    1. Lee HJ, et al. Oncotarget. 2017 Dec 14;9(1):924-936.

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