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LDN-0212320

Chemical Structure : LDN-0212320

CAS No.: 894002-50-7

LDN-0212320 (LDN212320, OSU-0212320)

Catalog No.: PC-61675Not For Human Use, Lab Use Only.

LDN0212320 (OSU 0212320) is a small-molecule activator of glutamate transporter EAAT2 translation with EC50 of 1.83 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

LDN-0212320 (OSU 0212320) is a small-molecule activator of glutamate transporter EAAT2 translation with EC50 of 1.83 uM.
LDN-0212320 activates PKC and subsequent Y-box-binding protein 1 (YB-1), which regulates activation of EAAT2 translation; protects cultured neurons from glutamate-mediated excitotoxic injury and death via EAAT2 activation in a murine model.
LDN-0212320 markedly delays motor function decline and extends lifespan in an animal model of ALS, reduces mortality, neuronal death, and spontaneous recurrent seizures in a pilocarpine-induced temporal lobe epilepsy model.

Physicochemical Properties

M.Wt 293.39
Formula C17H15N3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine

References

1. Kong Q, et al. J Clin Invest. 2014 Mar;124(3):1255-67.

2. Takahashi K, et al. J Exp Med. 2015 Mar 9;212(3):319-32.

3. Chelini A, et al. J Med Chem. 2017 Jun 22;60(12):5216-5221.

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