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Chemical Structure : LDN-0212320
CAS No.: 894002-50-7
Catalog No.: PC-61675Not For Human Use, Lab Use Only.
LDN0212320 (OSU 0212320) is a small-molecule activator of glutamate transporter EAAT2 translation with EC50 of 1.83 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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LDN-0212320 (OSU 0212320) is a small-molecule activator of glutamate transporter EAAT2 translation with EC50 of 1.83 uM.
LDN-0212320 activates PKC and subsequent Y-box-binding protein 1 (YB-1), which regulates activation of EAAT2 translation; protects cultured neurons from glutamate-mediated excitotoxic injury and death via EAAT2 activation in a murine model.
LDN-0212320 markedly delays motor function decline and extends lifespan in an animal model of ALS, reduces mortality, neuronal death, and spontaneous recurrent seizures in a pilocarpine-induced temporal lobe epilepsy model.
| M.Wt | 293.39 | |
| Formula | C17H15N3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine |
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1. Kong Q, et al. J Clin Invest. 2014 Mar;124(3):1255-67.
2. Takahashi K, et al. J Exp Med. 2015 Mar 9;212(3):319-32.
3. Chelini A, et al. J Med Chem. 2017 Jun 22;60(12):5216-5221.
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