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Chemical Structure : LDN193189 hydrochloride
CAS No.: 1062368-62-0
Catalog No.: PC-42885Not For Human Use, Lab Use Only.
LDN193189 is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM, displays >200-fold selectivity for BMP signaling over TGF-β signaling (IC50>1,000 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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LDN193189 hydrochloride is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM, displays >200-fold selectivity for BMP signaling over TGF-β signaling (IC50>1,000 nM).
LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7.
LDN193189 also blocks the transcriptional activity induced by either constitutively active ALK2 R206H or ALK2 Q207D mutant proteins, affects BMP-induced osteoblast differentiation, attenuates ectopic ossification in vivo.
| M.Wt | 552.3261 | |
| Formula | C25H26Cl4N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: 20 mg/mL |
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| Chemical Name/SMILES |
Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-, hydrochloride (1:1) |
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1. Yu PB, et al. Nat Med. 2008 Dec;14(12):1363-9.
2. Cuny GD, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4388-92.
3. Cannon JE, et al. Br J Pharmacol. 2010 Sep;161(1):140-9.
4. Steinbicker AU, et al. Blood. 2011 May 5;117(18):4915-23.
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