LEAP2
(LEAP-2, Human liver expressed antimicrobial peptide-2)
Catalog No.: PC-26750Not For Human Use, Lab Use Only.
LEAP2 (Liver expressed antimicrobial peptide-2, LEAP-2) is an endogenous peptide antagonist of ghrelin receptor (GHSR) with IC50 of 6 nM on GHSR activation in the presence of ghrelin.
LEAP2 (Liver expressed antimicrobial peptide-2, LEAP-2) is an endogenous peptide antagonist of ghrelin receptor (GHSR) with IC50 of 6 nM on GHSR activation in the presence of ghrelin.
LEAP2 inhibits the receptor with potency similar to that with which ghrelin activates the receptor.
LEAP2 is a noncompetitive antagonist of GHSR, likely modulating the receptor through binding to an allosteric site.
LEAP2 is highly and specifically expressed in enterocytes along the luminal surface of the villi, but not in lamina propria or crypts.
LEAP2 antagonizes ghrelin-induced growth hormone secretion and food intake in mice.
